Effects of luteolin and quercetin in combination with some conventional antibiotics against methicillin-resistant Staphylococcus aureus
Articolo
Data di Pubblicazione:
2016
Citazione:
Effects of luteolin and quercetin in combination with some conventional antibiotics against methicillin-resistant Staphylococcus aureus / M.U. Amin, M. Khurram, T.A. Khan, H.S. Faidah, Z.U. Shah, S. Ur Rahman, A. Haseeb, M. Ilyas, N. Ullah, S.M.U. Khayam, M. Iriti. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 17:11(2016), pp. 1947.1-1947.16. [10.3390/ijms17111947]
Abstract:
The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics were determined and results showed an increased activity of flavonoids with antibiotics. The synergistic, additive, or antagonistic relationships between flavonoids (L and Q + L) and antibiotics were also evaluated, and additive and synergistic effects were observed for some antibiotic + flavonoid combinations. In addition, some combinations were also found to damage the bacterial cytoplasmic membrane, as assessed through potassium leakage assay. The effects of flavonoids and flavonoids + antibiotics on mecA gene mutations were also tested, and no functional variation was detected in the coding region.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
antibiotic resistance; combination therapy; flavonoids; MRSA; phytochemicals; synergism; catalysis; molecular biology; computer science applications; computer vision and pattern recognition; spectroscopy; physical and theoretical chemistry; organic chemistry; inorganic chemistry
Elenco autori:
M.U. Amin, M. Khurram, T.A. Khan, H.S. Faidah, Z.U. Shah, S. Ur Rahman, A. Haseeb, M. Ilyas, N. Ullah, S.M.U. Khayam, M. Iriti
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