Data di Pubblicazione:
2017
Citazione:
In search of the transcriptional blueprints of a competent oocyte / R. Pasquariello, V. Bocchi, T. Brevini, F. Gandolfi. - In: ANIMAL REPRODUCTION. - ISSN 1806-9614. - 14:1(2017), pp. 34-47. [10.21451/1984-3143-AR894]
Abstract:
The oocyte undergoes a remarkably long and elaborated journey within the follicle before becoming fully equipped to sustain embryonic development. Its ability to support early embryonic development relies largely on the maternal transcripts accumulated during its growth and maturation. However, it is still not clear what transcriptome blueprint composes a competent oocyte. A number of extensive studies provided a detailed characterization of the mRNA molecules that are gradually accumulated in the oocyte cytoplasm. The detail of our knowledge has gradually increased through the years also thanks to the development and improvement of the analytical techniques. From real-time PCR analysis of single transcripts, to the whole transcriptome approach of gene arrays and new genereation sequencing, scientists accumulated an exponentially growing amount of new information. More recently, the discovery of non-coding RNAs revealed a new layer of complexity in the mechanisms that modulate gene expression at the mRNA level, in folliculogenesis and oogenesis. In particular, data are emerging on the potential role of microRNAs in controlling ovarian function, oocyte maturation and the oocyte-somatic cell cross talk. This review will try to summarize the vast amount of data currently available on the mRNAs and microRNAs associated with the ovarian function and to find their biological significance.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Competence; Folliculogenesis; Oocyte; Transcriptome; Animal Science and Zoology; Veterinary (all)
Elenco autori:
R. Pasquariello, V. Bocchi, T. Brevini, F. Gandolfi
Link alla scheda completa: