Lipopolysaccharide biogenesis and transport at the outer membrane of Gram-negative bacteria
Articolo
Data di Pubblicazione:
2016
Citazione:
Lipopolysaccharide biogenesis and transport at the outer membrane of Gram-negative bacteria / P. Sperandeo, A.M. Martorana, A. Polissi. - In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. - ISSN 1388-1981. - (2016 Oct 16). [Epub ahead of print]
Abstract:
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer containing a unique glycolipid, lipopolysaccharide (LPS) in its outer leaflet. LPS molecules confer to the OM peculiar permeability barrier properties enabling Gram-negative bacteria to exclude many toxic compounds, including clinically useful antibiotics, and to survive harsh environments. Transport of LPS poses several problems to the cells due to the amphipatic nature of this molecule. In this review we summarize the current knowledge on the LPS transport machinery, discuss the challenges associated with this process and present the solutions that bacterial cells have evolved to address the problem of LPS transport and assembly at the cell surface. Finally, we discuss how knowledge on LPS biogenesis can be translated for the development of novel antimicrobial therapies. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ABC transporter; drug discovery; lipopolysaccharide transport; outer membrane biogenesis; sensing LPS defects; molecular biology; cell biology
Elenco autori:
P. Sperandeo, A.M. Martorana, A. Polissi
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