Data di Pubblicazione:
1993
Citazione:
Molecular determinants of insulin action / C.R. Kahn, F. Folli. - In: HORMONE RESEARCH. - ISSN 0301-0163. - 39:suppl. 3(1993), pp. 93-101.
Abstract:
Insulin rapidly stimulates tyrosine phosphorylation of a 185-kDa protein in most cell types. This protein, insulin receptor substrate 1 (IRS-1), has been implicated as the first postreceptor step in insulin signal transmission based on studies with insulin receptor mutants. In cell culture and in vitro, phosphory-lated IRS-1 associates with the lipid-metabolizing enzyme phosphatidylinosi-tol 3-kinase (PI 3-kinase), resulting in activation of this enzyme. Thus, the insulin receptor, IRS-1 and PI-3 kinase represent three of the earliest steps in insulin action at the cellular level. We have recently demonstrated that insulin is capable of stimulating PI 3-kinase activity in liver and muscle in vivo in animals and that IRS-1 phosphorylation may play a significant role in the association/activation with PI 3-kinase in vivo.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
insulin; phosphorylation; insulin receptors; insulin receptor substrate-1; phosphoinositol 3-kinase
Elenco autori:
C.R. Kahn, F. Folli
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