Microvolt T-wave alternans for risk stratification in athletes with ventricular arrhythmias : correlation with programmed ventricular stimulation
Articolo
Data di Pubblicazione:
2008
Citazione:
Microvolt T-wave alternans for risk stratification in athletes with ventricular arrhythmias : correlation with programmed ventricular stimulation / G. Inama, C. Pedrinazzi, O. Durin, M. Nanetti, G. Donato, R. Pizzi, D. Assanelli. - In: ANNALS OF NONINVASIVE ELECTROCARDIOLOGY. - ISSN 1082-720X. - 13:1(2008), pp. 14-21. [10.1111/j.1542-474X.2007.00196.x]
Abstract:
Background: Aim of our study is to evaluate the role of T-wave alternans (TWA) to stratify the risk of sudden cardiac death in athletes (Ath) with complex ventricular arrhythmias (VA), and to document a possible correlation between TWA and electrophysiological testing (EPS) results.
Methods: We studied 85 Ath with VA (61 M, mean age 32 +/- 11 years). In all cases a cardiological evaluation was performed, including TWA and EPS. The patients were evaluated during a follow-up of 30 +/- 21 months. The end point was the occurrence of sudden death (SD) or malignant ventricular tachyarrhythmias (VT).
Results: TWAwas negative in 57 Ath (68%), positive in 15 (18%) and indeterminate in 13 (14%). All subjects with negative TWA did not show induction of VT at EPS, with significant correlation between negative TWA and negative EPS (P < 0.001). All Ath with positive TWA also had VT induced by a EPS, with significant correlation (P < 0.001). By contrast, our data did not show significant correlation between indeterminate TWA and positive or negative EPS. However, there was significant correlation between abnormal TWA test (positive + indeterminate) and inducibility of VT at EPS (P < 0.001). During follow-up we observed a significant difference in end point occurrence (VT or SD) between Ath with negative or abnormal TWA and between Ath with negative or positive EPS.
Conclusion: TWA confirm its role as a simple and noninvasive test, and it seems useful for prognostic stratification of Ath with VA.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
T-wave alternans; sudden death; ventricular arrhythmias; sport activity
Elenco autori:
G. Inama, C. Pedrinazzi, O. Durin, M. Nanetti, G. Donato, R. Pizzi, D. Assanelli
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