Advantage of endoscopic-ultrasound-fine-needle aspiration associated to Sendai clinical guidelines in detecting the malignant risk in patients with undetermined pancreatic cysts: Long-term follow-up
Articolo
Data di Pubblicazione:
2016
Citazione:
Advantage of endoscopic-ultrasound-fine-needle aspiration associated to Sendai clinical guidelines in detecting the malignant risk in patients with undetermined pancreatic cysts: Long-term follow-up / P. Gambitta, P. Aseni, P. Fontana, E. Bareggi, E. Forti, A. Tringali, F. Molteni, M. Vertemati. - In: INTERNATIONAL JOURNAL OF HEPATOBILIARY AND PANCREATIC DISEASES. - ISSN 2230-9012. - 6:2(2016 Nov), pp. 100062IJHPDPG2016.100-100062IJHPDPG2016.107. [10.5348/ijhpd-2016-62-OA-18]
Abstract:
Aims: Contradictory information exists on whether different clinical guidelines are effective in detecting the malignant risk in patients with pancreatic cysts. We have retrospectively evaluated the accuracy and the long-term outcome in patients with pancreatic cysts with
a diameter ≥ 2 cm when indication for surgery was established by clinical evaluation of their malignant risk according to Sendai Clinical
Guidelines associated to endoscopic-ultrasoundfine-needle aspiration. Methods: Patients with pancreatic cysts with a diameter ≥2 cm were
evaluated for their potential malignant risk by endoscopic-ultrasound-fine-needle aspiration associated to the clinical evaluation by Sendai
Clinical Guidelines. Long-term outcome and comparison in patients survival as well as the accuracy in detecting malignancies were
evaluated with the combined clinical and endoscopic evaluation. Results: Two hundred eighteen patients with pancreatic cysts were
observed during a 9-year period of the study and 74 of them (33.9%) presenting with a pancreatic cyst ≥ 2 cm were eligible for the study.
Fourteen malignant neoplasms (18.9%) were detected. The accuracy in detecting malignancy of combined clinical and endoscopic evaluation
was very high (0.99). The five-year survival rates for patients who underwent surgery with benign and malignant pancreatic cysts and
for patients in observational follow-up were similar (70% and 85%). The cohort of patients with malignant pancreatic cysts with ductal
adenocarcinoma showed a five-year survival rate of 41%. Conclusion: Endoscopic ultrasound fineneedle aspiration associated to Sendai clinical guidelines showed a high accuracy in detecting malignant risk in patients with pancreatic cysts with a diameter ≥ 2 cm. allowing appropriate selection for surgical treatment with satisfactory long-term survival.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
diagnostic imaging; pancreatic cancer; pancreatic carcinoma; pancreatic neoplasm; pancreatic pseudocyst
Elenco autori:
P. Gambitta, P. Aseni, P. Fontana, E. Bareggi, E. Forti, A. Tringali, F. Molteni, M. Vertemati
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