2,4-Furfurylidene-D-sorbitol and its tetra-methyl ether: Synthesis, conformational studies, and radical scavenging activity
Articolo
Data di Pubblicazione:
2016
Citazione:
2,4-Furfurylidene-D-sorbitol and its tetra-methyl ether: Synthesis, conformational studies, and radical scavenging activity / P. Ciuffreda, A. Brizzolari, S. Casati, I. Eberini, L. Palazzolo, C. Parravicini, E. Santaniellob. - In: ARKIVOC. - ISSN 1551-7004. - 2016:5(2016 Aug), pp. 50-68. [10.3998/ark.5550190.p009.690]
Abstract:
The structure of 1-[2-(furan-2-yl)-5-hydroxy-6-(hydroxymethyl)-1,3-dioxan-4-yl]ethane-1,2-diol] (2,4-furfurylidene-D-sorbitol) and its tetra-methyl ether was established by a detailed NMR analysis. The conformational structure for both compounds was confirmed by in silico studies based both on Density Functional Theory (DFT) and on classical molecular dynamics approaches. The scavenging activity against hydroxyl radicals (•OH) of compounds was established by the 2 deoxyribose degradation assay.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
2,4-furfurylidene-d-sorbitol; 2,4-furfurylidene-d-sorbitol tetra-methyl ether; conformational studies; hydroxyl radicals scavenging activity; molecular modeling; nmr spectroscopy; organic chemistry
Elenco autori:
P. Ciuffreda, A. Brizzolari, S. Casati, I. Eberini, L. Palazzolo, C. Parravicini, E. Santaniellob
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