Data di Pubblicazione:
2007
Citazione:
Effects of rosuvastatin on endothelial and vascular wall gene expression / G.D. Norata, P. Marchesi, K. Garlaschelli, A.L. Catapano. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 8:1(2007 Jun), pp. 200-200. (Intervento presentato al 76. convegno EAS Congress tenutosi a Helsinki nel 2007) [10.1016/S1567-5688(07)71761-0].
Abstract:
Background: A body of evidence is accumulating suggesting a role
for statins in endothelial function, including anti-inflammatory and proangiogenic
activities. To address this issue, we investigated the gene
expression patterns induced by rosuvastatin in vitro in endothelial cells and
in vivo in apoE-/- mice.
Methods and Results: In human endothelial cells (HUVECs and
HAEC) treatment with rosuvastatin 10μM induced eNOS, VEGF and KDR
expression relative to cell under control conditions. For in vivo studies, 20
apoE-/- mice were fed with a cholesterol rich diet, plus rosuvastatin 10
mg/kg/day, and 10 mice with only the cholesterol rich diet. Rosuvastatin
treatment reduced plasma levels of total cholesterol (TC) and triglycerides
(TG) by 42% and by 22% respectively (p<0.05). The lesion area in the
ascending aorta was reduced by 50.3% in animals treated with rosuvastatin
(19725±7860μm2 vs 39697±18712μm2 p=0.06). Collagen deposition
was reduced at the ascending aorta level (22.76±6.3% vs 36.58±13.1%
p<0.05). mRNA levels for a-actin in the vascular wall were reduced while
no difference was observed in the expression of CD68, CD4, IL6, IL10,
MCP-1, eNOS, VEGF and TF.
Summary: in vitro rosuvastatin treatment resulted in eNOS, KDR
and VEGF mRNA induction both in HUVECS and HAEC cells. In vivo
rosuvastatin treatment in Apo E KO mice fed a cholesterol rich diet resulted
in decreased atherosclerosis mainly at the ascending aorta, paralleled by a decreased expression of markers for smooth muscle cells, while no changes in macrophages and T-lymphocytes were observed
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G.D. Norata, P. Marchesi, K. Garlaschelli, A.L. Catapano
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