Data di Pubblicazione:
2016
Citazione:
Lithium overdosage and related tests / P.D. Pigatto, B. Dell'Osso, G. Guzzi. - In: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS. - ISSN 2194-7511. - 4(2016), pp. 1.1-1.1. [10.1186/s40345-015-0044-y]
Abstract:
Lithium acts biochemically through the inositol depletion in brain cortex. At low doses, however, it is partly effective and/or ineffective, whereas in high concentrations is toxic. We would like to make one point about this review. In fact, in our view, the patient should be given a support to correct hypernatremia and even sodium levels should be tested serially-along with serum lithium concentrations-because high sodium levels reduce the rate of elimination of lithium. Lithium is mainly a neurotoxicant. Lithium-related central nervous system toxicity as well as the cardiovascular and thyroid changes are most likely due to the cations (Na2 (+) and K(+)) competition.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P.D. Pigatto, B. Dell'Osso, G. Guzzi
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