Data di Pubblicazione:
2005
Citazione:
L'importanza del macrofago nella malattia tubercolare / S. Aliberti, S. Della Patrona. - In: GIMT. GIORNALE ITALIANO DELLE MALATTIE DEL TORACE. - ISSN 1127-0810. - 59:1(2005), pp. 27-31.
Abstract:
Mycobacterium tuberculosis is an intracellular pathogen with a particular defensive systems allowing its survival, and even growth, inside the hostile environment constituted by the macrophage. Such cell is provided with killing mechanisms consisting in reactive oxygen and nitrogen intermediates and is coadiuvated, in this microbicidal ativity, by the gamma-interpheron produced by the T-Lymphocyte. The mycobacterium, by its side, has the property of limiting such microbicidal macrophage activity thank to the production of adequate enzymatic systems. Opposed to these defensive properties of the microorganism, GSH (as well as its precursor N-acetylcysteine) is essential for the intracellular killing of the mycobacterium both directly and through the production of GSNO.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Gamma interpheron; GSH; GSNO; Macrophage. T-lymphocyte; Mycobacterium; N-acetylcysteine; Reactive nitrogen species; Reactive oxygen species; Pulmonary and Respiratory Medicine
Elenco autori:
S. Aliberti, S. Della Patrona
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