Evaluation of an heterogeneous group of patients with von Willebrand disease using an assay alternative to ristocetin induced platelet agglutination
Articolo
Data di Pubblicazione:
2015
Citazione:
Evaluation of an heterogeneous group of patients with von Willebrand disease using an assay alternative to ristocetin induced platelet agglutination / F. Stufano, L. Baronciani, M.T. Pagliari, F. Franchi, G. Cozzi, I. Garcia Oya, P. Bucciarelli, M. Boscarino, F. Peyvandi. - In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. - ISSN 1538-7933. - 13:10(2015 Oct), pp. 1806-14-1814. [10.1111/jth.13062]
Abstract:
Diagnosis of von Willebrand disease (VWD) type 2 usually relies on the discrepancy between the von Willebrand factor (VWF) ristocetin cofactor activity (VWF:RCo) and VWF antigen (VWF:Ag). Type 2B patients can be discriminated from other qualitative VWD variants by using ristocetin-induced platelet agglutination (RIPA) test. The major limitation of RIPA is the requirement of fresh blood sample.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
GPIbalpha protein, human; ristocetin; von Willebrand disease, type 2; von Willebrand diseases; von Willebrand factor; Biomarkers; Blood Platelets; Case-Control Studies; Diagnosis, Differential; Humans; Mutation; Platelet Glycoprotein GPIb-IX Complex; Predictive Value of Tests; Protein Multimerization; Ristocetin; Severity of Illness Index; von Willebrand Disease, Type 2; von Willebrand Factor; Platelet Aggregation; Platelet Function Tests
Elenco autori:
F. Stufano, L. Baronciani, M.T. Pagliari, F. Franchi, G. Cozzi, I. Garcia Oya, P. Bucciarelli, M. Boscarino, F. Peyvandi
Link alla scheda completa: