Data di Pubblicazione:
2016
Citazione:
Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation / R. Bonecchi, C. Garlanda, A. Mantovani, F. Riva. - In: CYTOKINE. - ISSN 1043-4666. - (2016 Aug 04). [Epub ahead of print]
Abstract:
IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atypical chemokine receptor; Chemokine; Innate immunity; Interleukin-1; Regulation of inflammation
Elenco autori:
R. Bonecchi, C. Garlanda, A. Mantovani, F. Riva
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