Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts
Articolo
Data di Pubblicazione:
2016
Citazione:
Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts / M. Sharifi Rad, G.S. Tayeboon, J. Sharifi Rad, M. Iriti, E.M. Varoni, S. Razazi. - In: CELLULAR AND MOLECULAR BIOLOGY. - ISSN 1165-158X. - 62:6(2016 May), pp. 80-85. [10.14715/cmb/2016.62.6.15]
Abstract:
Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P<0.05) inhibited α-glucosidase (IC50 532.97 µg/mL), whereas conjugated phenolic extract significantly (P<0.05) inhibited α-amylase (IC50 489.73 µg/mL) and ACE (290.06 µg/mL). The enzyme inhibitory activities of the extracts were not associated with their phenolic content. Anyway, the inhibition of α-amylase, α-glucosidase and ACE, along with the antioxidant capacity of the phenolic-rich extracts, could represent a putative mechanism through which V. persica exerts its antidiabetes and antihypertension effects.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
angiotension; converting enzyme; ethnopharmacology; Plantaginaceae; traditional medicine; α-amylase; α-glucosidase
Elenco autori:
M. Sharifi Rad, G.S. Tayeboon, J. Sharifi Rad, M. Iriti, E.M. Varoni, S. Razazi
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