Data di Pubblicazione:
2015
Citazione:
Csf p-tau181/tau ratio as biomarker for TDP pathology in frontotemporal dementia / B. Borroni, A. Benussi, S. Archetti, D. Galimberti, L. Parnetti, B. Nacmias, S. Sorbi, E. Scarpini, A. Padovani. - In: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. - ISSN 2167-8421. - 16:1-2(2015 Mar), pp. 86-91. [10.3109/21678421.2014.971812]
Abstract:
Our objective was to evaluate the CSF phospho-Tau181/total-Tau (p/t-Tau) ratio to distinguish between the two main forms of frontotemporal lobar degeneration (FTLD): FTLD with TDP-43 (FTLD-TDP) and FTLD with Tau inclusions (FTLD-Tau). CSF p/t-Tau ratio was examined in 79 FTLD patients with predictable neuropathology, i.e. Tau (affected by progressive supranuclear palsy or carriers of mutations within the MAPT gene) or TDP-43 (carriers of mutations within granulin, C9orf72, TARDBP genes or affected by FTD with motor neuron disease). FTLD patients were randomly grouped in a training cohort (n = 39) to assess the best CSF p/t-Tau cut-off score according to ROC analysis, and a validation cohort (n = 40) to evaluate accuracy values of the identified marker. Results showed that, in the training cohort, we found a significantly reduced CSF p/t-Tau ratio in FTLD-TDP relative to FTLD-Tau. ROC analysis for p/t-Tau ratio was 0.873 and cut-off score of 0.136 allowed to differentiate FTLD-TDP and FTLD-Tau with 81.8% sensitivity and 88.2% specificity, respectively. Analysis in the validation cohort showed CSF p/t-Tau ratio < 0.136 to distinguish FTLD-TDP from FTLD-Tau with 83.3% specificity and 63.6% sensitivity, respectively. The positive predictive value of detecting TDP neuropathology was 82.4%. In conclusion, a reduced CSF p/t-Tau ratio represents a viable biomarker to correctly identify TDP pathology in FTLD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amyloid beta-peptides/cerebrospinal fluid; Biological markers/cerebrospinal fluid; Frontotemporal lobar degeneration/cerebrospinal fluid; Peptide fragments/cerebrospinal fluid; Tau proteins/cerebrospinal fluid; Aged; Aged, 80 and over; Amyloid beta-Peptides; Cohort Studies; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Female; Frontotemporal Dementia; Humans; Italy; Male; Middle Aged; Peptide Fragments; Phosphorylation; tau Proteins; Neurology (clinical); Neurology; Medicine (all)
Elenco autori:
B. Borroni, A. Benussi, S. Archetti, D. Galimberti, L. Parnetti, B. Nacmias, S. Sorbi, E. Scarpini, A. Padovani
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