Clostridium difficile infection epidemiology and management : Comparison of results of a prospective study with a retrospective one in a reference teaching and research hospital in Northern Italy
Articolo
Data di Pubblicazione:
2016
Citazione:
Clostridium difficile infection epidemiology and management : Comparison of results of a prospective study with a retrospective one in a reference teaching and research hospital in Northern Italy / G. Domeniconi, S. Serafino, M. Migone De Amicis, S. Formica, M. Lanzoni, A. Maraschini, F. Sisto, D. Consonni, M.D. Cappellini, G. Fabio, S. Castaldi. - In: AMERICAN JOURNAL OF INFECTION CONTROL. - ISSN 0196-6553. - 44:11(2016 Jun 29), pp. 1214-1218. [10.1016/j.ajic.2016.05.003]
Abstract:
Background: Clostridium difficile-associated disease (CDAD) is the most common infectious antibiotic-associated diarrhea and is a growing health care problem. Prevention of Clostridium difficile infection focuses on clinical and epidemiologic infection control measures. Methods: Between 2008 and 2009, we conducted a retrospective study that showed an incidence of CDAD among the highest reported in the literature. Subsequently, we developed a preventive protocol that was adopted in our hospital in 2010. We then conducted a prospective study to investigate prevalence, incidence, and mortality of CDAD and to compare the results with those of the retrospective study, evaluating adherence to preventive measures and their efficacy. Results: In both studies, prevalence and incidence significantly increased in older patients. Crude prevalence was similar in the 2 studies. The incidence rate increased by 36%, with a significant increase only in the C and D wards. In-hospital mortality rose in both prevalent and incident cases. Regarding adhesion to hospital protocol, 77% of prevalent cases were treated with the required procedure. The highest percentage of isolated patients was achieved in C and D wards. In these wards we detected lower training hours per nurse. However, in 2013, we observed a significant decrease in incidence of CDAD and found a hospital prevalence of 0.33%. Conclusions: Health care personnel education could be more important than the possibility of isolating infected patients in single rooms.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
clostridium difficile infection; epidemiology; management
Elenco autori:
G. Domeniconi, S. Serafino, M. Migone De Amicis, S. Formica, M. Lanzoni, A. Maraschini, F. Sisto, D. Consonni, M.D. Cappellini, G. Fabio, S. Castaldi
Link alla scheda completa: