Data di Pubblicazione:
2004
Citazione:
The nitration of τ protein in neurone-like PC12 cells / G. Cappelletti, G. Tedeschi, M.G. Maggioni, A. Negri, S. Nonnis, R. Maci. - In: FEBS LETTERS. - ISSN 0014-5793. - 562:1-3(2004), pp. 35-39.
Abstract:
Tyrosine nitration of proteins is emerging as a post-translational modification playing a role in physiological conditions. Looking for the molecular events triggered by nitric oxide in nerve growth factor-induced neuronal differentiation, we now find that nitration occurs on the microtubule-associated protein tau In differentiated PC12 cells, we have identified as tau a nitrated protein that co-immunoprecipitates with alpha-tubulin and indicated that modified protein is associated with the cytoskeleton but it is confined to a restricted cell region. This paper supplies the first evidence that nitation of occurs in a physiological process and suggests that it could play a role in neuronal differentiation.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Cappelletti, G. Tedeschi, M.G. Maggioni, A. Negri, S. Nonnis, R. Maci
Link alla scheda completa: