Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation
Articolo
Data di Pubblicazione:
2016
Citazione:
Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation / I. Saulle, M. Biasin, F. Gnudi, V. Rainone, S. Ibba, S. Lo Caputo, F. Mazzotta, D. Trabattoni, M. Clerici. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 32:2(2016 Feb), pp. 129-133.
Abstract:
Analyses of immune activation in HIV-exposed seronegative individuals (HESN) yielded discrepant results. To
clarify this issue we performed an extensive investigation of immune parameters in HESN and, in particular, we
analyzed in these individuals the possible presence of microbial translocation, the most widely accepted reason
driving immune activation in HIV-infected patients. Results showed that immune activation, a skewing of
T lymphocyte maturation, and increased responsiveness to lipopolysaccharide (LPS) characterize the HESN
phenotype; this is not driven by alterations of the gastrointestinal barrier and microbial translocation. The
activation state seen in HESN may influence the induction of stronger adaptive antiviral immune responses and
may represent a virus exposure-induced innate immune protective phenotype against HIV.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
I. Saulle, M. Biasin, F. Gnudi, V. Rainone, S. Ibba, S. Lo Caputo, F. Mazzotta, D. Trabattoni, M. Clerici
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