A refined multiscale self-Entropy approach for the assessment of cardiac control complexity: application to long QT syndrome type 1 patients
Articolo
Data di Pubblicazione:
2015
Citazione:
A refined multiscale self-Entropy approach for the assessment of cardiac control complexity: application to long QT syndrome type 1 patients / V. Bari, G. Girardengo, A. Marchi, B. De Maria 5, P.A. Brink, L. Crotti, P.J. Schwartz, A. Porta. - In: ENTROPY. - ISSN 1099-4300. - 17:(2015), pp. 7768-7785. [10.3390/e17117768]
Abstract:
The study proposes the contemporaneous assessment of conditional entropy
(CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE)
decomposition, as a function of the time scale via refined multiscale CE (RMSCE) and sE
(RMSsE) with the aim at gaining insight into cardiac control in long QT syndrome type 1
(LQT1) patients featuring the KCNQ1-A341V mutation. CE was estimated via the
corrected CE (CCE) and sE as the difference between the ShE and CCE. RMSCE and RMSsE were computed over the beat-to-beat series of heart period (HP) and QT interval
derived from 24-hour Holter electrocardiographic recordings during daytime (DAY)
and nighttime (NIGHT). LQT1 patients were subdivided into asymptomatic and
symptomatic mutation carriers (AMCs and SMCs) according to the severity of symptoms
and contrasted with non-mutation carriers (NMCs). We found that RMSCE and RMSsE
carry non-redundant information, separate experimental conditions (i.e., DAY and NIGHT)
within a given group and distinguish groups (i.e., NMC, AMC and SMC) assigned the
experimental condition. Findings stress the importance of the joint evaluation of RMSCE
and RMSsE over HP and QT variabilities to typify the state of the autonomic function and
contribute to clarify differences between AMCs and SMCs.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
V. Bari, G. Girardengo, A. Marchi, B. De Maria 5, P.A. Brink, L. Crotti, P.J. Schwartz, A. Porta
Link alla scheda completa: