Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species
Articolo
Data di Pubblicazione:
2016
Citazione:
Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species / S. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. - In: PEPTIDOMICS. - ISSN 2084-7203. - 2:1(2016), pp. 29-34. [10.1515/ped-2015-0004]
Abstract:
Amyotrophic Lateral Sclerosis (ALS) has often been associated with improper/altered metal metabolism. Analysis of thiophylic metals in serum from a small and geographically restricted cohort of ALS patients indicates contents of Pb and Ni much higher in patients than in controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in the patients’ group, which has instead lower As levels than controls. Thiophylic metals may impair biogenesis of FeS clusters or substitute for iron, even in folded proteins; Se may non-functionally replace S. Thus, improper assembly/function of FeS proteins could represent another possible issue to be considered in ALS pathogenesis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amyotrophic Lateral Sclerosis, Serum metals, ICP-MS, Iron Sulfur Clusters
Elenco autori:
S. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi
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