Transformation of canine lymphoma/leukemia to more aggressive diseases : anecdotes or reality?
Articolo
Data di Pubblicazione:
2015
Citazione:
Transformation of canine lymphoma/leukemia to more aggressive diseases : anecdotes or reality? / S. Comazzi, L. Aresu, L. Marconato. - In: FRONTIERS IN VETERINARY SCIENCE. - ISSN 2297-1769. - 2(2015 Oct 07), pp. 42.1-42.6. [10.3389/fvets.2015.00042]
Abstract:
Transformation is the evolution of an indolent lymphoma/leukemia to an aggressive
lymphoma, typically harboring a very poor prognosis. This phenomenon is well described
in humans, but underestimated in dogs although recognized as a possible evolution
of indolent lymphomas/leukemias. In canine chronic leukemias, blast crisis (mainly in
myeloid) and Richter syndrome (transformation into a high grade lymphoma) (mainly in
B-cell lymphocytic leukemia) have been reported. Transformation is a possible event
also in canine low grade lymphomas, although rare. The increased knowledge has also
generated new questions and posed challenges that need to be addressed to improve
outcome, including the recognition of the clinical characteristics at diagnosis associated
with a higher risk of transformation in an attempt of anticipating the typical evolution.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
DLBCL; Richter syndrome; blast crisis; dog; indolent; leukemia; lymphoma; transformation
Elenco autori:
S. Comazzi, L. Aresu, L. Marconato
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