Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection
Articolo
Data di Pubblicazione:
2015
Citazione:
Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection / P. Sacchi, S. Cima, M. Corbella, G. Comolli, A. Chiesa, F. Baldanti, C. Klersy, S. Novati, P. Mulatto, M. Mariconti, C. Bazzocchi, M. Puoti, L. Pagani, G. Filice, R. Bruno. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 47:3(2015 Mar), pp. 218-225. [10.1016/j.dld.2014.11.012]
Abstract:
Background: Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims: We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods: This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results: Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups (p<. 0.0005). FIB-4 and liver stiffness values inversely correlated with TGF-β1 (p= 0.0155 and p= 0.0498). Bacterial DNA differed significantly in the HIV-positive compared to the other groups: HIV/HCV co-infected subjects had significantly higher serum levels of bacterial translocation products, CD14, and IL-17 levels (p<. 0.001). Conclusions: Fibrosis stage in HIV/HCV co-infection may be influenced by immune activation due either by viral infections or to bacterial translocation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bacterial translocation; HIV immunity; HIV/HCV co-infection; Liver fibrosis
Elenco autori:
P. Sacchi, S. Cima, M. Corbella, G. Comolli, A. Chiesa, F. Baldanti, C. Klersy, S. Novati, P. Mulatto, M. Mariconti, C. Bazzocchi, M. Puoti, L. Pagani, G. Filice, R. Bruno
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