Data di Pubblicazione:
2016
Citazione:
Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films / I. Franceschini, F. Selmin, S. Pagani, P. Minghetti, F. Cilurzo. - In: CARBOHYDRATE POLYMERS. - ISSN 0144-8617. - 136:(2016 Jan 20), pp. 10379.676-10379.681. [10.1016/j.carbpol.2015.09.077]
Abstract:
One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached. As a consequence, PVAc nanoparticles was found to be an effective reinforcing agent only at the concentrations of 3 and 5% w/w. In this optimal range, the tensile strength increased at least 1.5 fold and the elastic modulus increased at least 4 times.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Casting solution; Maltodextrins; Mechanical reinforcement; Nanofiller; Orodispersible films; Tensile properties; Organic Chemistry; Materials Chemistry2506 Metals and Alloys; Polymers and Plastics
Elenco autori:
I. Franceschini, F. Selmin, S. Pagani, P. Minghetti, F. Cilurzo
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