Immunomodulatory effects in a phase II study of lenalidomide combined with cetuximab in refractory KRAS-mutant metastatic colorectal cancer patients
Articolo
Data di Pubblicazione:
2013
Citazione:
Immunomodulatory effects in a phase II study of lenalidomide combined with cetuximab in refractory KRAS-mutant metastatic colorectal cancer patients / A.K. Gandhi, T. Shi, M. Li, U. Jungnelius, A. Romano, J. Tabernero, S. Siena, P.H. Schafer, R. Chopra. - In: PLOS ONE. - ISSN 1932-6203. - 8:11(2013 Nov 11), pp. e80437.1-e80437.10. [10.1371/journal.pone.0080437]
Abstract:
This study assessed the immunomodulatory effects in previously treated KRAS-mutant metastatic colorectal cancer patients participating in a phase II multicenter, open-label clinical trial receiving lenalidomide alone or lenalidomide plus cetuximab. The main findings show the T cell immunostimulatory properties of lenalidomide as the drug induced a decrease in the percentage CD45RA+ naïve T cells 3-fold while increasing the percentage HLA-DR+ activated T helper cells and percentage total CD45RO + CD8+ memory T cytotoxic cells, 2.6- and 2.1-fold respectively (p<0.0001). In addition, lenalidomide decreased the percentage of circulating CD19+ B cells 2.6-fold (p<0.0001). Lenalidomide increased a modest, yet significant, 1.4-fold change in the percentage of circulating natural killer cells. Our findings indicate that lenalidomide significantly activates T cells, suggestive of an immunotherapeutic role for this drug in settings of maintenance therapy and tumor immunity. Furthermore, reported for the first time is the effect of lenalidomide in combination with cetuximab on T cell function, including increases in circulating naïve and central memory T cells. In summary, lenalidomide and cetuximab have significant effects on circulating immune cells in patients with colorectal carcinoma. © 2013 Gandhi et al.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Humans; Mutation; Proto-Oncogene Proteins; Thalidomide; ras Proteins; Agricultural and Biological Sciences (all); Biochemistry, Genetics and Molecular Biology (all); Medicine (all)
Elenco autori:
A.K. Gandhi, T. Shi, M. Li, U. Jungnelius, A. Romano, J. Tabernero, S. Siena, P.H. Schafer, R. Chopra
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