Analysis of NSCLC tumor heterogeneity, proliferative and 18F-FDG PET indexes reveals Ki67 prognostic role in adenocarcinomas
Articolo
Data di Pubblicazione:
2016
Citazione:
Analysis of NSCLC tumor heterogeneity, proliferative and 18F-FDG PET indexes reveals Ki67 prognostic role in adenocarcinomas / A. Del Gobbo, A. Pellegrinelli, G. Gaudioso, M. Castellani, F. Zito Marino, R. Franco, A. Palleschi, M. Nosotti, S. Bosari, V. Vaira, S. Ferrero. - In: HISTOPATHOLOGY. - ISSN 0309-0167. - 68:5(2016 Apr), pp. 746-751. [10.1111/his.12808]
Abstract:
AIMS:
The role of tumour metabolic and proliferative indices in predicting non-small-cell lung cancer (NSCLC) patients' prognosis is unclear. We correlated fluorine 18 (18 F)-fluorodeoxyglucose (FDG)-positron emission tomography (PET) value and Ki67 index to patients' survival, taking into account tumour heterogeneity, disease characteristics and genetic aberrations.
METHODS AND RESULTS:
A series of 383 NSCLCs was arranged into tissue microarrays and Ki67 staining was analysed by immunohistochemistry. The maximum standardized uptake (SUVMAX ) value detected by 18 F-FDG-PET analysis was calculated over a region of interest. Large-cell and squamous cell carcinomas had higher proliferative and metabolic activities than adenocarcinomas, and the two measures were correlated significantly. The hot-spot Ki67 value was correlated with patients' survival and the cut-off to discriminate patients in the survival risk groups was 20%. Ki67 hot-spot values were greater in anaplastic lymphoma kinase (ALK) rearranged tumours. Adenocarcinomas showed the highest intratumour heterogeneity in proliferative activity and the hot-spot Ki67 value predicted only the prognosis of patients in this group. Although tumour metabolic activity was not associated with patients' prognosis, a SUVMAX > 2 was related to nodal metastases, tumour size and grade.
CONCLUSIONS:
Our results highlight how tumour heterogeneity influences evaluation of prognostic biomarkers. Our data support Ki67 evaluation to estimate NSCLC patients' prognosis, particularly for adenocarcinoma.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
PET; Ki67; adenocarcinoma; lung cancer
Elenco autori:
A. Del Gobbo, A. Pellegrinelli, G. Gaudioso, M. Castellani, F. Zito Marino, R. Franco, A. Palleschi, M. Nosotti, S. Bosari, V. Vaira, S. Ferrero
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