Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted beta(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications
Articolo
Data di Pubblicazione:
2015
Citazione:
Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted beta(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications / A. Bonetti, S. Pellegrino, P. Das, S. Yuran, R. Bucci, N. Ferri, F. Meneghetti, C. Castellano, M. Reches, M.L. Gelmi. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 17:18(2015 Sep 18), pp. 4468-4471. [10.1021/acs.orglett.5b02132]
Abstract:
The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β(2,3)-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Drug-delivery system; peptide nanotubes; amino-acid; nanostructures; derivatives; helix; inducer; ph
Elenco autori:
A. Bonetti, S. Pellegrino, P. Das, S. Yuran, R. Bucci, N. Ferri, F. Meneghetti, C. Castellano, M. Reches, M.L. Gelmi
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