Data di Pubblicazione:
2015
Citazione:
Glycosyl hydroperoxides: a new class of potential antimalarial agents / B. Szechner, A. Jaromin, S. Parapini, N. Basilico, B. Grzeszczyk, B. Furman, M. Chmielewski. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 23:13(2015 Jul 01), pp. 3033-3039. [10.1016/j.bmc.2015.05.009]
Abstract:
Motivated by the antimalarial properties observed in organic peroxides, an extensive series of glycosyl hydroperoxides was prepared with the aim of identifying new bioactive molecules. Selected compounds were tested against a Plasmodium falciparum culture (chloroquine-susceptible strain D10 and chloroquine-resistant strain W2). Screening results indicated that the factors critical for antimalarial activity were the presence of a hydroperoxide moiety and solubility in water at pH 5.0. Moreover, the ability to inhibit β-hematin formation in vitro has been evaluated (BHIA Assay).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Hydroperoxides; Antimalarial compounds; Glycosides
Elenco autori:
B. Szechner, A. Jaromin, S. Parapini, N. Basilico, B. Grzeszczyk, B. Furman, M. Chmielewski
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