Data di Pubblicazione:
2014
Citazione:
Extramedullary conjunctival plasmacytoma in a cat / C. Giudice, N. D’Anna, C. Schiano, A. Guandalini, M. Rondena. - In: VETERINARY OPHTHALMOLOGY. - ISSN 1463-5216. - 17:1(2014), pp. 14.E11-14.E11. ((Intervento presentato al convegno Annual Scientific Meeting of the European College of Veterinary Opthalmologists tenutosi a Barcelona (Spain) nel 2013 [10.1111/vop.12135].
Abstract:
Purpose: To describe a case of solitary conjunctival plasmacytoma in a cat. Methods: A
9 year-old female Domestic shorthaired cat was referred with a 3 weeks history of protrusion
of the left third eyelid. Results: Ophthalmic examination showed conjunctival hyperemia
and a smooth nodule on the bulbar aspect of the third eyelid. Globe retropulsion was normal.
Cytologic smears of the mass revealed sheets of round cells with eccentric nucleus,
characteristic cartwheel appearance, and abundant cytoplasm with clear perinuclear halo,
highly suggestive of plasmacytoma. Accurate stadiation was performed excluding clinical
signs of multiple myeloma. The third eyelid was excised and submitted for histology. Histologically,
a poorly defined neoplastic mass, 1.5 cm in diameter, expanded nictitans conjunctiva
substituting lacrimal gland. The mass was composed of dense sheets of round cells
morphologically consistent with mature plasma cells. Anisocytosis and anisokaryosis were
mild and rare binucleated giant cells were observed. Mitoses were rare. Neoplastic cells were
immunohistochemically positive for CD20 and lambda chains and negative for CD3. Based
on histological, immunophenotypical and clinical findings a diagnosis of extramedullary plasmacytoma
of the third eyelid was posed. No recurrence has been noted 5 months after surgery.
Conclusions: Conjunctival solitary extramedullary plasmacytoma is a rare tumor in
human beings. In the feline species, intraocular and orbital but not conjunctival solitary
plasmacytomas have been reported so far. Since in the cat, in contrast to human, well differentiated
myeloma commonly have extramedullary involvement, in the diagnosis of solitary
plasmacytoma it is important to rule out a myeloma-related disorder.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Giudice, N. D’Anna, C. Schiano, A. Guandalini, M. Rondena
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