Histological and immunohistochemical features of a recurrent epithelial-myoepithelial lacrimal gland tumor in a dog
Poster
Data di Pubblicazione:
2014
Citazione:
Histological and immunohistochemical features of a recurrent epithelial-myoepithelial lacrimal gland tumor in a dog / C. Giudice, D. Multari. - In: VETERINARY OPHTHALMOLOGY. - ISSN 1463-5216. - 17:1(2014), pp. 41.E15-41.E15. (Intervento presentato al convegno Annual Scientific Meeting of the European College of Veterinary Opthalmologists tenutosi a Barcelona (Spain) nel 2013) [10.1111/vop.12135].
Abstract:
Purpose: To describe histological and immunohistochemical features of a rare lacrimal
gland tumor. Methods: A conjunctival mass in the upper eyelid, lateral cantus, was surgically
excised from an 11 year-old female mongrel dog. Eight months later the dog presented
with recurrence of a larger orbital mass, and complete orbital exenteration was performed.
Samples from both surgeries were formalin fixed and submitted for histology. Microtomic
sections were stained with hematoxylin and eosin and serial sections immunostained with the
standard ABC method in order to characterize neoplastic cells. Monoclonal antibodies antivimentin,
cytokeratin 14 (CK14), CK19, CK8/18 and alpha smooth-muscle-actin (aSMA)
were applied. AEC served as the chromogen. Results: Histologically, the first mass excised
was a large, capsulated, neoplastic nodule with expansive growth. The second mass was a
large multilobulated un-encaspulated nodule with multifocal signs of infiltrative growth. In
both tumors two distinct cell populations were present: cuboidal cell lining small ductular
structure and elongated cells with scant, clear cytoplasm disposed in short bundles or in
whorls around ductal structures. Cuboidal cells were positive for CK19 and CK8/18, spindle
cells were CK14 and aSMA positive. Both cell types were vimentin negative. Based on histological
and immunohistochemical feature a diagnosis of epithelial-myoepithelial carcinoma
(ECM) was posed. Conclusions: ECM is a rare tumor of lacrimal gland, whose histological
features parallel those of salivary tumors, in which both component of secretory parenchyma,
i.e. epithelial and myoepithelial cells, undergo neoplastic transformation. Further
investigations are necessary to understand the specific prognostication criteria for this type
of neoplasm.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Giudice, D. Multari
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