Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration
Capitolo
Data di Pubblicazione:
2009
Citazione:
Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration / V. Magnaghi, P. Procacci, A.M. Tata (INTERNATIONAL REVIEW OF NEUROBIOLOGY). - In: Essays on peripheral nerve repair and regeneration / [a cura di] S. Geuna, P. Tos, B. Battiston. - New York : Elsevier, 2009. - ISBN 9780123750846. - pp. 295-315 [10.1016/S0074-7742(09)87015-3]
Abstract:
Peripheral neuropathies are common neurologic disorders, but current treatments are limited. Among the different approaches to treat the acquired neuropathies due to traumatic injuries, the pharmacological interventions directed to Schwann cell may represent a useful and challenging opportunity. Following nerve damage the distal axon and the ensheathing Schwann cells degenerate, ensuing a process known as "Wallerian degeneration". Schwann cells then dedifferentiate and proliferate to support neurite outgrowth.
In the recent years, several pharmacological agents that may promote the Schwann cell in its role of supporting nerve regeneration have been proposed. However, in view of increased understanding of the cellular mechanisms controlling neuron-glial interactions, a great attention has focused on neurotransmitters, neuroactive steroids, and neurohormones. In this review, we survey the latest findings on these factors and assess their potential as novel promising treatments for peripheral neuropathies caused by injury.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
dorsal-root ganglia; rat sciatic-nerve; increases intracellular calcium; muscarinic receptor subtypes; gamma-aminobutyric-acid; axonal gaba-receptors; sensory neurons; spinal-cord; neuroactive steroids; protein-kinase
Elenco autori:
V. Magnaghi, P. Procacci, A.M. Tata
Link alla scheda completa:
Titolo del libro:
Essays on peripheral nerve repair and regeneration