Data di Pubblicazione:
2011
Citazione:
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells / Z. Roberta, F. Alessandra, C. Monica, L. Dmitry, C. Antonio, P. Tracey, A. Cariboni, O. Grzegorz, N. Bemd, C.P. Luigi, D. Carla, A. Genazzani Armando. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 116:4(2011 Feb), pp. 606-615. [10.1111/j.1471-4159.2010.07144.x]
Abstract:
P>Calcium is a universal signal, and its capacity to encode intracellular messages via spatial, temporal and amplitude characteristics allows it to participate in most cellular events. In a specific context, calcium plays a pivotal role in migration, although its role has not been elucidated fully. By using immortalized gonadotropin-releasing hormone-secreting neurons (GN11), we have now investigated the role of TRPV4, a member of the vanilloid family of Ca2+ channels, in neuronal migration. Our results show that TRPV4 channels are present and functional in GN11 cells and their localization is polarized and enriched in lamellipodial structures. TRPV4 activation leads to a retraction of the lamellipodia and to a decrease in migratory behaviour; moreover cells migrate slower and in a more random manner. We therefore provide evidence for a new regulation of gonadotropin-releasing hormone neurons and a new role for calcium at the leading edge of migratory cells.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
calcium; gonadotropin-releasing hormone neurons; migration; TRPV4
Elenco autori:
Z. Roberta, F. Alessandra, C. Monica, L. Dmitry, C. Antonio, P. Tracey, A. Cariboni, O. Grzegorz, N. Bemd, C.P. Luigi, D. Carla, A. Genazzani Armando
Link alla scheda completa: