Cardiovascular control in women with fibromyalgia syndrome : do causal methods provide non redundant information compared to more traditional approaches?
Articolo
Data di Pubblicazione:
2015
Citazione:
Cardiovascular control in women with fibromyalgia syndrome : do causal methods provide non redundant information compared to more traditional approaches? / A.R. Zamunér, A. Porta, C. Pieroni Andrade, A. Marchi, M. Forti, R. Furlan, F. Barbic, A.M. Catai, E. Silva. - In: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. - ISSN 0363-6119. - 309:1(2015), pp. R79-R84. [10.1152/ajpregu.00012.2015]
Abstract:
The cardiovascular autonomic control and the baroreflex sensitivity (BRS) have been widely studied in FMS patients through the computation of linear indices of spontaneous heart period (HP) and systolic arterial pressure (SAP) variabilities. However, there are many methodological difficulties regarding the quantification of BRS by the traditional indices especially in relation to the issue of causality. This difficulty has been directly tackled via a model-based approach describing the closed loop HP-SAP interactions and the exogenous influences of respiration. Therefore, we aimed to assess if the BRS assessed by the model-based causal closed-loop approach during supine and active standing in patients with FMS could provide complementary information to those obtained by traditional indices based on time and frequency domains. The findings of this study revealed that, although the traditional methods to quantify BRS did not show any significant differences between groups, the causality analysis applied to the HP, SAP and respiratory series, through the model based closed loop approach, detected lower BRS in supine position as well as a blunted response to the orthostatic stimulus in patients with FMS compared to healthy control subjects. Also, the strength of the causal relation from SAP to HP (i.e., along the cardiac baroreflex) increased during the active standing only in the control subjects. The model-based closed-loop approach proved to provide important complementary information about the cardiovascular autonomic control in patients with FMS.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A.R. Zamunér, A. Porta, C. Pieroni Andrade, A. Marchi, M. Forti, R. Furlan, F. Barbic, A.M. Catai, E. Silva
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