Data di Pubblicazione:
2015
Citazione:
Carbohydrates: a phenol sandwich fights diabetes / A. Bernardi, S. Sattin. - In: NATURE CHEMICAL BIOLOGY. - ISSN 1552-4450. - 11:9(2015 Aug 18), pp. 635-636.
Abstract:
The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA–HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
carbohydrates; glycosidases; diabetes; amylase
Elenco autori:
A. Bernardi, S. Sattin
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