Synthesis, acid-base properties and preliminary cell compatibility evaluation of amphoteric poly(amido-hydrazine)s
Articolo
Data di Pubblicazione:
2005
Citazione:
Synthesis, acid-base properties and preliminary cell compatibility evaluation of amphoteric poly(amido-hydrazine)s / B. MALGESINI, P. FERRUTI, A. MANFREDI, M. CASOLARO, F. CHIELLINI. - In: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS. - ISSN 0883-9115. - 20:4(2005), pp. 377-394. [10.1177/0883911505055373]
Abstract:
Amphoteric poly(amido-hydrazine)s (PAHYs) were obtained by
hydrogen-transfer polyaddition of hydrazine, 1,2-dimethylhydrazine and 1,1-
dimethylhydrazine to 2,2-bisacrylamidoacetic acid. These polymers were studied
for biomedical applications, such as degradability in water solution, acid–base
properties, and cell toxicity. They degraded rapidly in aqueous media under physiological
conditions, their molecular weight was reduced to about one-fourth, that
of the original polymer in less than two days. They exhibited a typical polyelectrolyte
behavior with isoelectric points between 4 and 5 and are prevailingly
anionic in the blood. In preliminary cell toxicity essays they proved to be remarkably
biocompatible, comparable in this respect to amphoteric poly(amido-amine)s
(PAAs), and much less toxic than poly-L-lysine and polyethylenimine.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biocompatible polymers; Degradable polymers; Ionic polymers; Multifunctional polymers; Poly(amido-hydrazine)s
Elenco autori:
B. Malgesini, P. Ferruti, A. Manfredi, M. Casolaro, F. Chiellini
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