Data di Pubblicazione:
2015
Citazione:
Is chronic neutropenia always a benign disease? Evidences from a 5-year prospective study / B. Fattizzo, A. Zaninoni, D. Consonni, A. Zanella, U. Gianelli, A. Cortelezzi, W. Barcellini. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 26:8(2015 Oct), pp. 611-615. [10.1016/j.ejim.2015.05.019]
Abstract:
AIM:
To evaluate infections and oncohematologic evolution in adult patients with chronic idiopathic and autoimmune neutropenia in a prospective study.
PATIENTS AND METHODS:
76 consecutive patients were enrolled from September 2008 to April 2012. Complete blood counts and clinical evaluation were performed at enrolment, at month 3, 6, and then every 6 months. Anti-neutrophil antibodies were tested by GIFT method.
RESULTS:
Patients (49 chronic idiopathic- and 27 autoimmune neutropenia) were followed for a median of 5 years (range 24-84 months). At enrolment, neutropenia was mild in 44 patients (median neutrophils 1.27×10(3)/μL), moderate in 23 (median 0.8×10(3)/μL), and severe in 9 (median 0.4×10(3)/μL). Neutrophil counts showed a great inter-subject but no intra-subject variability, with lower values in autoimmune neutropenia, in males, and in MGUS cases. Over time, no grade >3 infections occurred; 13/49 chronic idiopathic and 6/27 autoimmune neutropenia patients experienced a grade 2 event, irrespective of mean and nadir neutrophil values. Bone marrow evaluation at enrolment showed reduced cellularity in 23% of cases, and dyserythropoietic features in 55%, with no definite hematologic diagnosis. During the follow-up, 5 cases were diagnosed with NK expansion, 4 with hairy cell leukemia, and 3 with myelodysplasia (1 myelomonocytic leukemia, 1 refractory cytopenia with unilineage dysplasia, and 1 multilineage dysplasia), with a median time to evolution of 30 months.
CONCLUSION:
Chronic idiopathic and autoimmune neutropenia, although usually benign, deserve hematological follow-up with a bone marrow evaluation at diagnosis and a re-evaluation in the presence of worsening neutropenia, appearance of additional cytopenias, and lymphocytosis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Autoimmune neutropenia; Chronic idiopathic neutropenia; Chronic NK expansion; Hairy cell leukemia; Myelodysplasia; Internal Medicine
Elenco autori:
B. Fattizzo, A. Zaninoni, D. Consonni, A. Zanella, U. Gianelli, A. Cortelezzi, W. Barcellini
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