A successful experimental model for intimal hyperplasia prevention using a resveratrol eluting balloon
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Data di Pubblicazione:
2015
Citazione:
A successful experimental model for intimal hyperplasia prevention using a resveratrol eluting balloon / V. Tolva, S. Mazzola, P. Zerbi, L. Calvillo, R. Casana, G. Parati, F. Selmin, M. Albertini, F. Cilurzo. ((Intervento presentato al convegno EuroPCR 2015 tenutosi a Paris nel 2015.
Abstract:
Objective: Restenosis due to intimal hyperplasia is a major clinical problem that compromises the success of angioplasty
and endovascular surgery. Resveratrol (RSV) has demonstrated a beneficial effect on restenosis from angioplasty. Unfortunately,
the physicochemical characteristics of RSV reduce the practicality of its immediate clinical application. This
work proposes an experimental model aiming to setup an intravessel, elutable, RSV-containing compound.
Methods: A 140 mg/mL RSV sterile injectable solution with a suitable viscosity for intravascular administration by drugdelivery
catheter (RSV-c) was prepared. This solution was locally administered in the common iliac artery of adult male
New Zealand White rabbits using a dedicated device (Genie; Acrostak, Geneva, Switzerland) after the induction of intimal
hyperplasia by traumatic angioplasty. The RSV concentrations in the wall artery were determined, and the thickness of the
harvested iliac arteries was measured over a 1-month period.
Results: The Genie catheter was applied in rabbit vessels, and the local delivery resulted in an effective reduction in restenosis
after plain angioplasty. Notably, RSV-c forced into the artery wall by balloon expansion might accumulate in the interstitial
areas or within cells, avoiding the washout of solutions. Magnification micrographs showed intimal proliferation was
significantly inhibited when RSV-c was applied. Moreover, no adverse events were documented in in vitro or in vivo studies.
Conclusions: RSV can be advantageously administered in the arterial walls by a drug-delivery catheter to reduce the risk of
restenosis.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
restenosis prevention, neointima, resveratrol, antioxidant
Elenco autori:
V. Tolva, S. Mazzola, P. Zerbi, L. Calvillo, R. Casana, G. Parati, F. Selmin, M. Albertini, F. Cilurzo
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