Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies
Articolo
Data di Pubblicazione:
2015
Citazione:
Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies / S. Caini, B. Gibelli, D. Palli, C. Saieva, M. Ruscica, S. Gandini. - In: CANCER CAUSES & CONTROL. - ISSN 0957-5243. - 26:4(2015 Apr), pp. 511-518. [10.1007/s10552-015-0546-z]
Abstract:
PURPOSE:
Thyroid cancer has a higher incidence in women than in men, and it has been hypothesized that hormonal factors may explain such disparity. We performed a meta-analysis of observational prospective studies to investigate the association between menstrual and reproductive variables and exogenous hormone use and the risk of thyroid cancer among women.
METHODS:
We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random effect models.
RESULTS:
Overall, 5,434 thyroid cancer cases from twenty-four papers were included. Increasing age at first pregnancy/birth (SRR 1.56, 95 % CI 1.01-2.42) and hysterectomy (SRR 1.43, 95 % CI 1.15-1.78) were associated with thyroid cancer risk. Women that were in menopause at enrolment had a reduced thyroid cancer risk (SRR 0.79, 95 % CI 0.62-1.01). No other menstrual, reproductive, and hormonal variable was associated with thyroid cancer risk.
CONCLUSIONS:
Menstrual and reproductive factors may play a role in the etiology of thyroid cancer, possibly through the mediation of estrogen receptors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Menstrual factors; Reproductive factors; Hormone use; Thyroid cancer; Meta-analysis
Elenco autori:
S. Caini, B. Gibelli, D. Palli, C. Saieva, M. Ruscica, S. Gandini
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