Click reaction as a useful tool to creatively combine pharmacophores : the case of Vismodegib
Articolo
Data di Pubblicazione:
2015
Citazione:
Click reaction as a useful tool to creatively combine pharmacophores : the case of Vismodegib / M.S. Christodoulou, M. Morib, R. Pantanoa, R. Alfonsic, P. Infanteb, M. Bottad, E, G. Damiaf, F. Riccif, P.A. Sotiropouloug, S. Liekensh, B. Bottai, D. Passarella. - In: CHEMPLUSCHEM. - ISSN 2192-6506. - 80:6(2015 Jun), pp. 938-943. [10.1002/cplu.201402435]
Abstract:
The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened (SMO) protein is part of the hedgehog signalling pathway that is inhibited by the lead compound Vismodegib. Based on molecular modeling suggestions, seven triazole derivatives of Vismodegib were synthesized and their biological effect on different endothelial, cancer and cancer stem cell lines is reported.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cancer stem cells; click chemistry; docking; hedgehog pathway; vismodegib
Elenco autori:
M.S. Christodoulou, M. Morib, R. Pantanoa, R. Alfonsic, P. Infanteb, M. Bottad, E, G. Damiaf, F. Riccif, P.A. Sotiropouloug, S. Liekensh, B. Bottai, D. Passarella
Link alla scheda completa: