Data di Pubblicazione:
2012
Citazione:
New insights into mutable collagenous tissues : an inspiring model for tissue regeneration / A.R. Ribeiro, A. Barbaglio, M. Sugni, C. Di Benedetto, A.P. Lima, S. Tricarico, M.J. Oliveira, C. Ribeiro, M.D. Candia Carnevali, I. Wilkie, M. Barbosa. ((Intervento presentato al convegno World Biomaterial Congress tenutosi a Chengdu nel 2012.
Abstract:
Echinoderm Mutable Collagenous Tissues (MCTs) undergo nervously mediated, drastic and reversible changes in their passive mechanical properties. MCT mutability is involved in autotomy, posture maintenance and motility, and, as a consequence, it influences echinoderm biology in all its aspects (nutrition, reproduction, habitat selection, self-defense and predatory behavior) representing a key-factor for the ecological success of the phylum. Besides this, MCT performance represents a topic of remarkable interest for many different applied fields. A biomimetic research route looks at MCTs as a source of inspiration for the development of smart and innovative biomaterials with a great potential for in vitro and in vivo applications when a controlled and reversible plasticization and/or stiffening of the extracellular matrix is required. The MIMESIS (Marine Invertebrates Models & Engineered Substrates for Innovative bio-Scaffolds) project has being developed within this scientific context. The selected echinoderm model is the common sea urchin Paracentrotus lividus. This project is based on a multidisciplinary approach combining functional biology with biomaterial engineering. A brief review of recent morphological, biomolecular, biomechanical and biochemical results on P.lividus MCTs are here presented in a biotechnological perspective, taking into account also a promising application regarding the use of MCT-derived substrata for cell culture studies.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
A.R. Ribeiro, A. Barbaglio, M. Sugni, C. Di Benedetto, A.P. Lima, S. Tricarico, M.J. Oliveira, C. Ribeiro, M.D. Candia Carnevali, I. Wilkie, M. Barbosa
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