Biotransformation of aromatic ketones and ketoesters with the non-conventional yeast Pichia glucozyma
Articolo
Data di Pubblicazione:
2014
Citazione:
Biotransformation of aromatic ketones and ketoesters with the non-conventional yeast Pichia glucozyma / M.L. Contente, F. Molinari, P. Zambelli, V. De Vitis, R. Gandolfi, A. Pinto, D. Romano. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 55:51(2014), pp. 7051-7053. [10.1016/j.tetlet.2014.10.133]
Abstract:
The non-conventional yeast Pichia glucozyma CBS 5766 has been used for the biotransformation of different aromatic ketones and ketoesters. The growth and biotransformation conditions were optimised for the reduction of acetophenone and under optimised conditions, propiophenone, butyrophenone and valerophenone were reduced to the corresponding (S)-alcohols with high yields and enantioselectivity. Ketoreductase(s) of Pichia glucozyma showed high catalytic activities also towards aromatic β- and γ-ketoesters, being often competitive with esterase(s). These concurrent activities allowed for the preparation of hydroxyesters, hydroxyacids and lactones often in a very selective manner.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aromatic ketones; Aromatic ketoesters; Reduction; Enantioselective; Ketoreductase; Esterase
Elenco autori:
M.L. Contente, F. Molinari, P. Zambelli, V. De Vitis, R. Gandolfi, A. Pinto, D. Romano
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