Appearance of strong transplantation antigens in non-immunogenic lymphoma following drug-treatment in vivo
Articolo
Data di Pubblicazione:
1980
Citazione:
Appearance of strong transplantation antigens in non-immunogenic lymphoma following drug-treatment in vivo / M.C. Fioretti, L. Romani, A. Bonmassar, D. Taramelli. - In: JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0163-0571. - 2:2(1980), pp. 189-212. [10.3109/08923978009026397]
Abstract:
A chemically induced lymphosarcoma line (LSBM-1) of C57BL/10 (H-2b) origin lacks detectable TATA and is scarcely immunogenic for H-2-incompatible congenic recipients. New antigenic specificities, defined as drug-mediated tumor antigen(s) (DMTA) were found in a subline (LBD-1) obtained by in vivo treatment of LSBM-1 with the anti-neoplastic agent dimethyl-1-triazeno-imidazole-carboxamide (DTIC) over several transplant generations. It was concluded that the presence of detectable TATA is not a prerequisite for the induction of new antigenic specificities (DMTA).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Antigens, Neoplasm; Dacarbazine; Female; Histocompatibility Antigens; Lymphoma; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Transplantation Immunology; Tumor Cells, Cultured
Elenco autori:
M.C. Fioretti, L. Romani, A. Bonmassar, D. Taramelli
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