[Silver(I)(Pyridine-Containing Ligand)] complexes as unusual catalysts for A3-coupling reactions
Articolo
Data di Pubblicazione:
2014
Citazione:
[Silver(I)(Pyridine-Containing Ligand)] complexes as unusual catalysts for A3-coupling reactions / M. Trose, M. Dell'Acqua, T. Pedrazzini, V. Pirovano, E. Gallo, E. Rossi, A. Caselli, G. Abbiati. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 79:16(2014 Aug 15), pp. 7311-7320.
Abstract:
Two original macrocyclic silver(I)(pyridine-containing ligand) complexes [Ag(I)(Pc-L)] were synthesized and characterized. Their ability to catalyze the coupling among aldehydes, terminal alkynes and amines (A3-coupling) was demonstrated. The reaction could be performed under conventional as well as dielectric heating. The catalysts were effective in both cases, but dielectric heating allowed a lower catalyst loading and reduced ratio among reaction partners in shorter reaction times. The reaction scope was broad, including aryl/alkyl aldehydes, aryl/alkyl acetylenes and secondary aliphatic amines. Some unprecedented propargylamines have been prepared. The new catalytic system was also tested with more challenging coupling partners such as aniline and ketones.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
aldehyde-alkyne-amine; one-post synthesis; C-H activation; containing macrocyclic ligands; 3-component coupling reactions; quaternary carbon center; PC-L-asterisk; asymmetric cyclopropanation; efficient synthesis; terminal alkynes
Elenco autori:
M. Trose, M. Dell'Acqua, T. Pedrazzini, V. Pirovano, E. Gallo, E. Rossi, A. Caselli, G. Abbiati
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