Influenza and other respiratory viruses involved in severe acute respiratory disease in northern Italy during the pandemic and post pandemic period (2009-2011)
Articolo
Data di Pubblicazione:
2014
Citazione:
Influenza and other respiratory viruses involved in severe acute respiratory disease in northern Italy during the pandemic and post pandemic period (2009-2011) / E. Pariani, M. Martinelli, M. Canuti, S.M. Jazaeri Farsani, B.B. Oude Munnink, M. Deijs, E. Tanzi, A. Zanetti, L. van der Hoek, A. Amendola. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6133. - 2014(2014 Jun 12), pp. 241298.1-241298.5. [10.1155/2014/241298]
Abstract:
Since 2009 pandemic, international health authorities recommended monitoring severe and complicated cases of respiratory
disease, that is, severe acute respiratory infection (SARI) and acute respiratory distress syndrome (ARDS). We evaluated the
proportion of SARI/ARDS cases and deaths due to influenza A(H1N1)pdm09 infection and the impact of other respiratory viruses
during pandemic and postpandemic period (2009–2011) in northern Italy; additionally we searched for unknown viruses in those
cases for which diagnosis remained negative. 206 respiratory samples were collected from SARI/ARDS cases and analyzed by realtime
RT-PCR/PCR to investigate influenza viruses and other common respiratory pathogens; also, a virus discovery technique
(VIDISCA-454) was applied on those samples tested negative to all pathogens. Influenza A(H1N1)pdm09 virus was detected in
58.3% of specimens, with a case fatality rate of 11.3%.The impact of other respiratory viruses was 19.4%, and the most commonly
detected viruses were human rhinovirus/enterovirus and influenza A(H3N2). VIDISCA-454 enabled the identification of one
previously undiagnosedmeasles infection. Nearly 22% of SARI/ARDS cases did not obtain a definite diagnosis. In clinical practice,
great efforts should be dedicated to improving the diagnosis of severe respiratory disease; the introduction of innovative molecular
technologies, as VIDISCA-454, will certainly help in reducing such “diagnostic gap.”
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acute respiratory distress syndrome (ARDS) ; Influenza A(H1N1)pdm09 virus ; Respiratory viruses ; Severe acute respiratory infection (SARI); VIDISCA.
Elenco autori:
E. Pariani, M. Martinelli, M. Canuti, S.M. Jazaeri Farsani, B.B. Oude Munnink, M. Deijs, E. Tanzi, A. Zanetti, L. van der Hoek, A. Amendola
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