Azole-resistant Aspergillus fumigatus in the environment of Northern Italy, May 2011 to June 2012
Articolo
Data di Pubblicazione:
2014
Citazione:
Azole-resistant Aspergillus fumigatus in the environment of Northern Italy, May 2011 to June 2012 / A. Prigitano, V. Venier, M. Cogliati, G. De Lorenzis, M.C. Esposto, A.M. Tortorano. - In: EUROSURVEILLANCE. - ISSN 1025-496X. - 19:12(2014 Mar 27), pp. 20747.1-20747.7.
Abstract:
In recent years acquired azole resistance in Aspergillus fumigatus has been
increasingly reported and a dominant mechanism of resistance (TR34/L98H) was
found in clinical and environmental isolates.The aim of the present study was to
investigate the prevalence of azole resistance in environmental A. fumigatus isolates
collected in Northern Italy.
A. fumigatus grew from 29 out of 47 soil samples analysed. Azole resistant isolates
were detected in 12.7% of the soil samples and in 20.7% of the soil samples containing
A. fumigatus. High minimal inhibitory concentrations of itraconazole, posaconazole and
voriconazole were displayed by nine isolates from six different soil samples, namely
apple orchard (1 sample), rose pot compost (2 samples), and cucurbit yields (3
samples). Seven out of nine resistant isolates harboured the same TR34/L98H
mutation of cyp51A.
These findings, together with the occurrence of resistant clinical isolates, suggest that
azole resistance should be considered in primary patient care.
suggest that azole resistance should be considered in primary patient care.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aspergillus ; azole-resistance M; Italy ; TR34/L98H mutation
Elenco autori:
A. Prigitano, V. Venier, M. Cogliati, G. De Lorenzis, M.C. Esposto, A.M. Tortorano
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