Data di Pubblicazione:
2014
Citazione:
Serum protein profiling of early and advanced stage Crohn's disease / C. Piras, A. Soggiu, V. Greco, A. Cassinotti, G. Maconi, S. Ardizzone, A. Amoresano, G. Bianchi Porro, L. Bonizzi, P. Roncada. - In: EUPA OPEN PROTEOMICS. - ISSN 2212-9685. - 3:(2014 Jun), pp. 48-59. [10.1016/j.euprot.2014.02.010]
Abstract:
Crohn's disease (CD) represents a highly debilitating disease of difficult diagnosis and increasing incidence. Serum protein profiling of early stage Crohn's disease (ES) CD was investigated in order to improve the comprehension of the very early pathologic mechanisms and to support the difficult diagnostic procedures currently available. Inflammatory proteins and complement 3 chain C (C3c) were over-represented during ES CD, clusterin, retinol binding protein, α1-microglobulin and transthyretin were under-represented. A C3c isoform was found to be present only during ES CD. By now, lack of specific antibodies to detect isoforms made it impossible to perform alternative validation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Crohn's disease ; 2D electrophoresis ; Comparative proteomics ; C3c complement ; Transthyretin
Elenco autori:
C. Piras, A. Soggiu, V. Greco, A. Cassinotti, G. Maconi, S. Ardizzone, A. Amoresano, G. Bianchi Porro, L. Bonizzi, P. Roncada
Link alla scheda completa: