Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: a 6-month prospective observational study
Articolo
Data di Pubblicazione:
2012
Citazione:
Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: a 6-month prospective observational study / A. Tagliabue, S. Bertoli, C. Trentani, P. Borrelli, P. Veggiotti. - In: CLINICAL NUTRITION. - ISSN 0261-5614. - 31:2(2012 Apr), pp. 246-249.
Abstract:
Background & aims: This 6-month prospective, single-arm observational study was designed to assess the effects of the KD on the nutritional status, resting energy expenditure (REE), and substrate oxidation in patients with drug-resistant epilepsy.
Methods: Eighteen patients with medically refractory epilepsy underwent assessment of body composition, REE, and substrate oxidation rates before and after 6 months of MD.
Results: Compared with baseline, there were no statistically significant differences at 6 months in terms of height, weight, BMI z-scores, and REE. However, the respiratory quotient decreased significantly (from 0.80 +/- 0.06 to 0.72 +/- 0.05,p < 0.001) whereas fat oxidation was significantly increased (from 50.9 +/- 25.2 mg/min to 97.5 +/- 25.7 mg/min, p < 0.001). Interestingly, we found that the increase in fat oxidation was the main independent predictor of the reduction in seizure frequency (beta = -0.97, t = -6.3, p < 0.05).
Conclusions: Administering a MD for 6 months in patients with medically refractory epilepsy increases fat oxidation and decreases the respiratory quotient, without appreciable changes in REE.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ketogenic diet; Drug-resistant epilepsy; Resting energy expenditure; Fat oxidation; Respiratory quotient
Elenco autori:
A. Tagliabue, S. Bertoli, C. Trentani, P. Borrelli, P. Veggiotti
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