The smart connective tissue of echinoderms: a materializing promise for biotech applications
Articolo
Data di Pubblicazione:
2013
Citazione:
The smart connective tissue of echinoderms: a materializing promise for biotech applications / A. Barbaglio, S. Tricarico, C. Di Benedetto, D. Fassini, A.P. Lima, A.R. Ribeiro, C.C. Ribeiro, M. Sugni, F. Bonasoro, I. Wilkie, M. Barbosa, M.D. Candia Carnevali. - In: CAHIERS DE BIOLOGIE MARINE. - ISSN 0007-9723. - 54:4(2013), pp. 713-720. ((Intervento presentato al 14. convegno International Echinoderm Conference tenutosi a Brussels nel 2012.
Abstract:
Echinoderm Mutable Collagenous Tissues (MCT5) undergo nervously mediated, drastic and reversible changes in their passive mechanical properties. MCT mutability is involved in autotomy, posture maintenance and motility, and, as a consequence, it influences all aspects of echinoderm biology (nutrition, reproduction, habitat selection, self-defense and predatory behavior) representing a key-factor for the ecological success of the phylum. Besides this, MCT performance represents a topic of remarkable interest for many different applied fields. A biomimetic research route looks at MCTs as a source of inspiration for the development of smart and innovative biomaterials with great potential for in vitro and in vivo applications when controlled and reversible plasticization and/or stiffening of the extracellular matrix is required. The MIMESIS (Marine Invertebrate Models & Engineered Substrates for Innovative bio-Scaffolds) project has been developed within this scientific context. The selected echinoderm model is the common sea urchin Paracentrotus lividus. This project is based on a multidisciplinary approach combining functional biology with biomaterial engineering. A brief review of recent morphological, biomolecular, biomechanical and biochemical results on P lividus MCTs are here presented in a biotechnological perspective, taking into account also a promising application regarding the use of MCT-derived substrata for cell culture studies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biomaterials ; Collagen ; Echinoderm ; Mutable collagenous tissue ; Sea urchin
Elenco autori:
A. Barbaglio, S. Tricarico, C. Di Benedetto, D. Fassini, A.P. Lima, A.R. Ribeiro, C.C. Ribeiro, M. Sugni, F. Bonasoro, I. Wilkie, M. Barbosa, M.D. Candia Carnevali
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