Hepatitis B virus infection and immunosoppressive therapy in patients with inflammatory bowel disease
Articolo
Data di Pubblicazione:
2011
Citazione:
Hepatitis B virus infection and immunosoppressive therapy in patients with inflammatory bowel disease / F. Morisco, F. Castiglione, A. Rispo, T. Stroffolini, R. Vitale, S. Sansone, R. Granata, A. Orlando, R. Marmo, G. Riegler, M. Vecchi, L. Biancone, N. Caporaso. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 43:suppl. 1(2011), pp. S40-S48. ((Intervento presentato al convegno Update on Hepatitis B Disease : Clinical and Therapeutic Aspects tenutosi a Roma nel 2009.
Abstract:
Hepatitis B reactivation has been widely reported in patients undergoing immunosuppressive therapy in oncohaematological and transplant settings, with a high frequency of hepatic failure. This topic has received growing scientific interest and several studies reported the preventive effect of antiviral agents on hepatitis B reactivation during immunosuppression therapy. Routine prophylaxis is therefore recommended and specific recommendations were elaborated by AASLD, EASL and AISF.On the contrary, few data are available on the risk of HBV reactivation in patients with inflammatory bowel disease (IBD) receiving immunosuppressive therapy, and major questions regarding the optimal management (screening, prophylaxis, therapy, monitoring) of IBD patients with HBV infection remain to be addressed.The aim of this paper is to provide a systematic review of the literature to underline the main aspects of HBV infection and reactivation in patients affected by IBD treated with conventional or biological immunosuppressive drugs.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antivirals; Biological agents; HBV reactivation; Prophylaxis
Elenco autori:
F. Morisco, F. Castiglione, A. Rispo, T. Stroffolini, R. Vitale, S. Sansone, R. Granata, A. Orlando, R. Marmo, G. Riegler, M. Vecchi, L. Biancone, N. Caporaso
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