Enantiomerically Pure Bithiophene Diphosphine Oxides as Catalysts for Direct Double Aldol Reactions
Articolo
Data di Pubblicazione:
2013
Citazione:
Enantiomerically Pure Bithiophene Diphosphine Oxides as Catalysts for Direct Double Aldol Reactions / A. Genoni, M. Benaglia, S. Rossi, G. Celentano. - In: CHIRALITY. - ISSN 0899-0042. - 25:10(2013), pp. 643-647. [10.1002/chir.22190]
Abstract:
The direct aldol reaction between aryl methyl ketones with aromatic aldehydes in the presence of tetrachlorosilane and a catalytic amount of a chiral bithiophene diphosphine oxide was studied; the product of double aldol addition was isolated as diacetate in good diastereoselectivity (up to 95:5) and enantioselectivities up to 91%. The reaction with heteroaromatic aldehydes was also investigated leading to the corresponding 1,3 diols, in some cases with excellent stereoselectivities. Chirality 25:643-647:, 2013.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
aldol reaction; Lewis bases; organocatalysis; stereoselectivity; tetrachlorosilane
Elenco autori:
A. Genoni, M. Benaglia, S. Rossi, G. Celentano
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