Data di Pubblicazione:
2013
Citazione:
High-Density Lipoprotein Subfractions - What the Clinicians Need to Know / A. Pirillo, G.D. Norata, A.L. Catapano. - In: CARDIOLOGY. - ISSN 0008-6312. - 124:2(2013), pp. 116-125. [10.1159/000346463]
Abstract:
Although the inverse relationship between plasma levels of
high-density lipoprotein (HDL) and cardiovascular disease
has been largely demonstrated, many observations have
suggested that the assessment of HDL functionality might
be more informative than a simple measurement of HDLcholesterol
plasma levels. HDLs are a class of structurally and
functionally heterogeneous particles; in atherosclerosis-related
diseases, changes in HDL subfraction levels and functions
are frequently observed. Circulating levels of large HDL
particles are decreased in dyslipidaemic conditions, while
levels of small dense HDL particles are increased in patients
with coronary heart disease. Furthermore, specific genetic
defects in proteins involved in HDL metabolism significantly
impact the distribution of HDL subpopulations. Finally, many
drugs used for dyslipidaemia induce changes in HDL subfractions
strictly related to cardiovascular disease. Although
several methods exist to evaluate HDL subclass levels, most
of them are not easily applicable in clinical practice, due to
the costs and high variability. However, the possibility to
measure the levels of specific HDL subfractions in patients
with atherosclerosis-related diseases might help to better
define their cardiovascular risk.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Coronary heart disease; High-density lipoprotein; High-density lipoprotein function; High-density lipoprotein subpopulations
Elenco autori:
A. Pirillo, G.D. Norata, A.L. Catapano
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