Data di Pubblicazione:
2013
Citazione:
Cyclic isoDGR peptidomimetics as low-nanomolar αvβ 3 integrin ligands / M. Mingozzi, A. DAL CORSO, M. Marchini, I. Guzzetti, M. Civera, U. Piarulli, D. Arosio, L. Belvisi, D. Potenza, L. Pignataro, C. Gennari. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 19:11(2013), pp. 3563-3567. [10.1002/chem.201204639]
Abstract:
A perfect fit: Shown here is the docking best pose of a low-nanomolar αvβ3 integrin ligand cyclo[DKP-isoDGR] (atom color tube representation; see figure) into the receptor binding pocket, overlaid on the bound conformation of Cilengitide (green tube representation). The extended isoDGR conformation permits all the important interactions with the extracellular domain of the alphavbeta3 integrin. The metal ion in the MIDAS region is represented by a magenta sphere.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
conformational analysis; diketopiperazines; molecular modeling; peptides; peptidomimetics
Elenco autori:
M. Mingozzi, A. DAL CORSO, M. Marchini, I. Guzzetti, M. Civera, U. Piarulli, D. Arosio, L. Belvisi, D. Potenza, L. Pignataro, C. Gennari
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